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Treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a multisystem disease, should target the pathophysiological aberrations (inflammatory and oxidative and nitrosative stress pathways), not the psychosocial “barriers” .... |
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M.E./C.F.S
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Written by Frank Twisk
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Friday, 19 March 2010 14:10 |
Intro in Dutch by Frank Twisk:
In het wetenschappelijke tijdschrift Patient Education and Counselling
leveren Maes en ondergetekende kritiek op een artikel van van Houdenhove ( klik hier), waarin laatstgenoemde stelt dat de omgaan-met-of-herstel-vraag irrelevant lijkt/is, en dat
patiënten op zoek moeten naar een nieuw evenwicht m.b.v. "een flexibele CGT-aanpak" (?).
Maes en Twisk daarentegen betogen dat de "behandeling" niet gericht moet zijn op
"psychosociale barrières die de patiënt weerhouden van een nieuw evenwicht" en CGT(/GET),
maar op immunologische afwijkingen (inflammatie etc.), infekties en de gevolgen van
(permanente) aktivering van het afweersysteem (nitrosatieve stress, channelopathie etc.)
Michael Maes
Received 4 November 2009 published online 19 March 2010.
Corrected Proof
Treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a multisystem disease, should target the pathophysiological aberrations (inflammatory and oxidative and nitrosative stress pathways), not the psychosocial “barriers” for a new equilibrium.
Abstract
In a recent article published by B. van Houdenhove and P. Luyten it is claimed that cognitive behavioral therapy and graded exercise therapy (CBT/GET) are evidence based and are the most adequate treatments to control symptoms and improve quality of life of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, these authors do not disclose that their own treatments at the Belgian CFS Reference Centers with CBT/GET have proven to have no clinical effects.
The Belgian minister declared in the parliament that CBT/GET at those centers are no curative therapies. Even more, measured by objective standards the CBT/GET approach has shown to be counterproductive. van Houdenhove and Luyten neglect or deny all scientific findings on the pathophysiology and possible medical treatments of ME/CFS. However, there is now a consensus that inflammatory and oxidative and nitrosative (IO&NS) pathways underpin the pathophysiology of ME/CFS in humans and in animal models as well. Human and animal data show that treatments which target IO&NS pathways are useful in treating ME/CFS. van Houdenhove and Luyten also propose that the time has come to shift treatment research in CFS from efficacy studies to effectiveness studies in ‘real life’.
In our opinion, future research should use a high throughput screening, made possible by the translational approach, in order to further examine the IO&NS pathways in detail; further delineate novel drug-targets in the IO&NS pathways and develop new drugs to treat this complex and serious medical disorder.
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A Constructive Debate With the CDC on the Empirical Case Definition |
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Research -
M.E./C.F.S
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Written by DePaul University, Chicago, IL, USA, Journal of Disability Policy Studies 2010; 20; 251, March 2010
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Saturday, 20 February 2010 21:14 |
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In the Journal of Disability Policy Studies 2010; 20; 251 (March 2010), Leonard A.Jason et all open up the debate with the CDC regarding the diagnostic criteria that have been adopted by the CDC. Patients, patient organizations and advocates have been questioning these criteria for years as they thought the criteria were too broad and did not specify the group of patients that they felt were true ME/CFS patients. If the criteria are too broad, and include other disorders, specific research would become impossible. Regardless of the official criteria, some research groups continued to use the - more specific - previous criteria.
Jason's group emphasizes the need to standardize procedures to identify CFS and calls for a halt to the inclusion of people with primary psychiatric conditions into research samples.
This item is translated into Dutch, Spanish and Italian; please click the flag buttons above
to read this item in your language.
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Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you |
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Research -
M.E./C.F.S
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Written by M. Maes & F.N Twisk
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Wednesday, 30 December 2009 14:35 |
Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you:
Disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.
There is evidence that disorders in inflammatory and oxidative and nitrosative (IO&NS) pathways and a lowered antioxidant status are important pathophysiological mechanisms underpinning myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS).
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NO/ONOO - Martin L. Pall PhD |
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M.E./C.F.S
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Written by Carla
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Friday, 04 May 2007 15:58 |
Professor Martin L. Pall gave a presentation on the Nitric Oxide component and how various theories of various researchers match last monday May 7th. 2007. An introduction to his latest book "Explaining Unexplained Illnesses" where he links 14 different disorders, from asthma and cancer to CFS and FM can be found when you click 'READ MORE'.
Professor Pall is also paying attention to the outdated psychological and psychiatric models that are being applied unjustly to patients with illdefined disorders. By reviewing all scientific and psychogenic models there is no more room for doubt. Where Asthma and MS where once considered psychological disorders, it now seems psychologists need a new source of income, which can be the only reason they persist illdefined disorders to be theirs to treat. Even if some cases are due to psychological factors, the body's chemistry has changed, without physiological intervention, a patient will not recover. The psychological approach has not cured Asthma nor MS, and it will not cure CFS and FM. It is time for a new course of action. click "read more" to see Quotes from Professor Pall and our evaluation on part of his book.
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Conference notes Spain, Dr. Nancy Klimas |
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M.E./C.F.S
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Written by Carla
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Thursday, 08 March 2007 17:08 |
Thursday 15 of February, of 2007, Dr. Klimas gave a conference that was translated by the Mrs. Clara Valverde, president of the LigaME/CFS. A review on the recent Congress of Florida was given as well. (Please open this item to print it in Spanish. Abra por favor este artículo para imprimirlo en español.){mosimage}All the assistants agreed to accept that: There is a genetic predispositionà there is a triggering factor (infection, toxic, etc) à That alters the endocrine, immune systems, neuroendocrin ("mediators") à which affects health in a permanent way. All the assistants agreed on an organic cause and nobody presented that the cause was psychological. Regarding the patients of CFS, is not considered an homogeneous group but is believed for a fact that there are subgroups of patients, according to how the illness develops in each one the patients.
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NI / NEI Research